This is way, way too much. It should worry you a little. Heck, it should should worry you a lot. She is taking about 50 times more than needed.
I take 2.5mg after a really busy day, 1.25 mg otherwise. And I am a big person - around 220 pounds - probably a lot bigger than your mom.
( I could trim the dose down. I just don’t like the sticky mess that results from chopping gummies into quarters and then into eighths.)
If she really feels no effect with, say, a 5mg dose, then the issue is not dosage, but absorption. As we get older, we often develop lots of damage to the intestinal walls.
She should be able to take 5mg and absorb enough in an hour or less to be guaranteed to sleep.
Everybody metabolizes things differently. A 600lb patient of Dr. Nowzaradan might see results with half a mg, while another 100lb person needs a lot more. There’s a lot of “science” involved here as hard as that may be to believe.
There is no known toxicity level. Not that I am advocating taking 100mg of the stuff but seeing someone say they need 20mg or 40mg for efficacy does not surprise me. I see it a lot actually. You’ll know when you take too much - vivid nightmares, headaches in the AM, etc. Commonly known as the Melatonin “Hangover”.
That’s why the MO is to start with half a mg and work your way up and not take more than your system needs.
Melatonin really isn’t a supplement, but it is in this country. Then again, there are plenty of OTC drugs for sleep.
The problem here really isn’t the news, it’s the messenger. I’ve never seen a more irresponsible thing released to the public like this in my nearly 30 years of experience.
This “Study” looks like something a Jr HS student put together. Maybe it’s not a as bad as it looks in terms of research, but the information we were given makes it hard to say anything more positive than that.
It wasn’t even actually presented at the conference. It was a TV screen “Poster” presentation. And I was looking through all the pictures from the event yesterday on the AHA’s site. I saw a picture of ever single spoken presentation and poster presentation and guess which one wasn’t there… Incredible.
Sort of. Melatonin works like a micronutrient but the pharmacological curve isn’t like minerals. In a healthy adult the pineal glad releases .1-.3 mg nightly into circulation
So the low doses aim to mimic biology
Supraphysiological doses flood receptors causing the “hangovers” the net day - but more importantly, they suppress natural release and raise cortisol/prolactin.
Higher doses have uses but in specific cases (someone suffering from high oxidative stress with suppression for instance but very very temporal and not how its being used as a supplement. It’s not Vitamin C.
Larger folks do have slightly greater distribution volume to reach but the receptor saturation still occurs at around > 2mg
So more than volume the other issues in the cascade matter and yes its super complicated.
All hail the our lord savior Ambien and his evil brother Restoril. Best pharmaceutical I have ever had for traveling East or when needing to sleep in a combat zone (AKA wife is mad).
If Folk are having trouble sleeping and melatonin doesn’t work and magnesium isn’t helping then look at your RBC Magnesium/RBC Potassium, IGF-1 and prolactin and CRP numbers, AM/PM Cortisol, DHEA-S and full Thyroid panel - that would be the best starting point.
Relying on Tradnazone (offlabel), Ambien, Restoril etc are force ctrl+alt+delete to power your brain down. None of these restore pineal-hypothalamus-adrenal feedback loop that govern sleep. Long term, it will make matter worse.
I’m not sure how Oz got mixed up with them. He’s got a pretty solid resume compared to everyone else. Yea, his show was a little weird but it supported our industry so we didn’t mind.
The guy invented the Mitra-Clip. Been around for a long time and has saved a lot of lives.
In all honesty. You’re comparing apples to cinder blocks here. I’ve actually met Dr. Oz. He was at an annual conference at Nature’s Bounty I was at many moons ago. He’s not a murderer or Jeff.
Oz, whose parents were Turkish immigrants, was raised in Wilmington, Delaware, where his father was a thoracic surgeon. After graduating from Harvard University (1982), he earned an M.D. degree from the University of Pennsylvania School of Medicine and an M.B.A. from the Wharton School of Business in 1986. During this time, Oz, who was a dual citizen of the United States and Turkey, served in the Turkish army in order to maintain his citizenship in that country.
And someone else went to Wharton and has a string of bankruptcy scandals. I’m lost as to why credentialism and having a co-patent/invention absolves one of the many many incorrect and absolutely false claims a person puts forth?
This entire thread was started on calling out faulty scientific research put forth. To which I brought up RFK’s multiple recent statements in jest and further added Oz in the same boat for doing things along the same vain in his entire career. To which you wondered why I brought up Oz, which I thought was a joke, but realize now that you don’t see connection. RFK and Oz both hold positions of authority in the government today.
I said a dude can be bad and do a good thing and a dude could do something entirely great and hold a ludicrous position - yes by analogy.
To which you said apples and oranges because he’s not really the bad person in my analogy, to which I responded, he’s also also not the genius we all hold in great esteem (Einstein)
Your response is: he’s a nice dude that you’ve met and he went to Harvard and has a invention.
Cool.
But how does that absolve him of the many false claims he’s made and one recent one he made very publicly related to health?
